Our technology

Phenotype first.Biology chooses the molecules.

Instead of starting from a single target, we screen for the cellular behavior we want to change, then design, test, and learn in one continuous loop.

The discovery engine

Connected disciplines.One continuous loop.

Phenotypic screening, AI and molecular modeling, mechanism studies, and in vivo evaluation feed each other continuously. Evidence from any point can redirect the chemistry.

Diagram of the Nebula Discovery Engine linking phenotypic screening, AI and molecular modeling, mechanism and multi-omics, and in vivo validation, leading to therapeutic candidates.
Capabilities

Built to workas one system.

Cellular and animal studies run alongside chemistry and modeling, not after them, so each result can shape the next decision.

Drug screening

Chemical-library screening and quantitative phenotypic assays.

Drug design

Medicinal chemistry and structure–activity relationships.

High-content imaging

Multiparametric analysis of cellular responses.

AI/ML discovery

Data-informed compound prioritization and experiment selection.

In vitro models

Cellular models of senescence, aging, and disease.

In vivo evaluation

Program-specific evaluation in appropriate animal models.

Disease context

Multiple cancers, including bladder, breast, melanoma, lung, and renal cancer; liver, lung, and kidney fibrosis; and neurodegeneration. Evaluation scope varies by program.

From molecule to physiology

Every scalein conversation.

Chemistry, cell phenotypes, and whole-organism biology inform each other. Results in animal models can send us back to the bench as readily as cellular data move us forward.

Illustration of the discovery path: drug vials and a small molecule, multi-well screening plates, a mouse in a behavioral maze, and brain imaging.
MoleculesDesigned and refined by medicinal chemistry, with AI/ML support.
PhenotypesSenescence measured directly in cells by high-content imaging.
PhysiologyTissue health and function evaluated in animal models.
Together, further

Advance the science.Expand the possibilities.

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