# Nebula Longevity

> Nebula Longevity is a biotechnology startup discovering gerotherapeutics: medicines that target the underlying biology of aging and the diseases it drives. Its current focus is senotherapeutics, including senolytics (which selectively remove senescent cells) and senomorphics (which modulate their harmful signaling). Oncology is the lead program; fibrosis and neurodegeneration are in discovery.

Contact: info@nebulalongevity.com
Website: https://www.nebulalongevity.com/

## Key facts
- Mission: gerotherapeutic drug discovery for diseases that share the biological drivers of aging.
- Current focus: cellular senescence and senotherapeutics (senolytics and senomorphics).
- Approach: phenotype-first discovery that connects phenotypic drug screening, drug design and medicinal chemistry, high-content imaging, AI/ML-assisted discovery, and evaluation in cellular and animal models. In vitro and in vivo work inform each other continuously rather than as fixed sequential stages.
- Pipeline (compound identities are not disclosed):
  - NL-101, oncology (solid tumors including bladder, breast, melanoma, lung, and renal cancers): preclinical evaluation.
  - NL-102, liver fibrosis: discovery.
  - NL-103, lung fibrosis: discovery.
  - NL-104, kidney fibrosis: discovery.
  - NL-105, neurodegenerative disease: discovery.
  - No Nebula Longevity program has entered clinical testing.
- Separate healthy-aging path: selected natural-product candidates are being evaluated as potential nutraceuticals or dietary supplements, independently of the drug pipeline. No supplement product is currently available.

## Pages
- [Home](https://www.nebulalongevity.com/): overview, disease areas, and the screen, design, learn, validate approach.
- [Science](https://www.nebulalongevity.com/science): aging as a shared root of disease, cellular senescence as a hallmark of aging, and why oncology, fibrosis, and neurodegeneration.
- [Technology](https://www.nebulalongevity.com/technology): the Nebula Discovery Engine and core capabilities.
- [Pipeline](https://www.nebulalongevity.com/pipeline): programs NL-101 to NL-105 by stage, and the separate healthy-aging path.
- [Contact](https://www.nebulalongevity.com/contact): scientific collaboration, partnering, investment, and media inquiries.